Intestinal Disaccharidase Activity in Celiac Sprue (Gluten-Sensitive Enteropathy)

Jack D. Welsh, MD; Opal M. Zschiesche, MD; Juanetta Anderson; Anthony Walker, BS
Arch Intern Med. 1969;123(1):33-38. doi:10.1001/archinte.1969.00300110035006.
Text Size: A A A
Published online

Intestinal biopsy specimens from 22 patients with celiac sprue demonstrated the following: (1) Mean disaccharidase and alkaline phosphatase activities increased from low levels associated with severe mucosal lesions to higher levels with moderate or mild lesions. With mild histology, all enzymes assayed were normal, except for low lactase activity in 25%. (2) Comparison of paired specimens from adjacent sites revealed similar morphologic changes in 70% of the pairs. With respect to occurrence of normal or abnormal enzyme activity in the paired samples, lactase activity was the same in all pairs, while the other enzymes were the same in 74% to 86% of the pairs. (3) Although a clinical improvement followed fair adherence to a glutenfree diet, mild histologic changes and a complete return of enzyme activity occurred only in patients who had adhered strictly to the diet.


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 29

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.