0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Intestinal Disaccharidase Activity in Celiac Sprue (Gluten-Sensitive Enteropathy)

Jack D. Welsh, MD; Opal M. Zschiesche, MD; Juanetta Anderson; Anthony Walker, BS
Arch Intern Med. 1969;123(1):33-38. doi:10.1001/archinte.1969.00300110035006.
Text Size: A A A
Published online

Intestinal biopsy specimens from 22 patients with celiac sprue demonstrated the following: (1) Mean disaccharidase and alkaline phosphatase activities increased from low levels associated with severe mucosal lesions to higher levels with moderate or mild lesions. With mild histology, all enzymes assayed were normal, except for low lactase activity in 25%. (2) Comparison of paired specimens from adjacent sites revealed similar morphologic changes in 70% of the pairs. With respect to occurrence of normal or abnormal enzyme activity in the paired samples, lactase activity was the same in all pairs, while the other enzymes were the same in 74% to 86% of the pairs. (3) Although a clinical improvement followed fair adherence to a glutenfree diet, mild histologic changes and a complete return of enzyme activity occurred only in patients who had adhered strictly to the diet.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 29

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();