We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Early and Late Failures of Human Cadaveric Renal Allografts

Biman Khastagir, MB, BS; Andre Montandon, MD; Satoru Nakamoto, MD; Willem J. Kolff, MD, PhD
Arch Intern Med. 1969;123(1):8-14. doi:10.1001/archinte.1969.00300110010002.
Text Size: A A A
Published online


Causes of failure of 85 allografts in a series of 123 cadaver kidney transplantations were analyzed. Fifty-four failures (62%) occurred during the first three postoperative months, of which more than half occurred during the first month. Rejection (43.5%) was the most common cause of failure of an allograft, whereas infection was the most frequent cause of death of the host. Thrombosis of the renal artery occurred in eight of ten allografts when ABO blood groups were crossed from non-O-type donor to O-type recipient, but this complication was not seen when blood groups were crossed from O-type donor to non-O-type recipient. All recipients well matched by leukocyte antigens, and more than half of those who were mismatched, had good graft function and minimal rejection episodes. Thymectomy and splenectomy made no difference in the incidence of rejection, but predisposed the patients to fatal infections.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.