The series Progress in Brain Research is intended to be a multidisciplinary approach to problems in brain research, presenting "authoritative reviews and original articles by specially invited scientists." This volume deals with the clinical, pathological, physiological, and experimental aspects of carbon monoxide (CO) poisoning.
It offers a relatively complete review of the clinical manifestations of fatal CO poisoning coupled with rather detailed neuropathological evaluation. An attempt at clinical-pathological correlation is presented, and there is an excellent discussion in early chapters of possible mechanisms for the classical diphasic clinical course. Neurovascular phenomena and cerebral edema are presented as vital factors in the production of this picture. Similarities between the encephalopathies due to CO poisoning and other types of anoxic encephalopathy are pointed out. There is a brief review of the physiology of normal oxygenation and the manner by which CO produces clinical manifestations. A review of classical therapy is followed by