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Hashimoto's Thyroiditis and Turner's Syndrome

Carlos R. Hamilton Jr., MD; Marc Moldawer ,; Harvey S. Rosenberg, MD
Arch Intern Med. 1968;122(1):69-72. doi:10.1001/archinte.1968.00300060071015.
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The association between Turner's syndrome and hypothyroidism has been described on several occasions. In the reported cases, the X-isochromosome X karyotype has been observed in patients with Hashimoto's thyroiditis whereas the typical XO karyotype of Turner's syndrome has been associated with nongoitrous or primary hypothyroidism.1-5

This report describes a patient with Hashimoto's thyroiditis who was found to be chromatin negative and to have a 45-XO karyotype. She has the typical features of Turner's syndrome with the exception of a normal menstrual history.

Patient Summary  The patient (00-32-50), a 64-year-old white woman, was seen in the Endocrine Clinic at Ben Taub General Hospital for management of hypothyroidism. She was noted to have many of the clinical features of Turner's syndrome, but gave a history of normal menstrual periods between the ages of 14 and 42 years. Although she was married for the last seven of her theoretically fertile years,


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