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The Use of Antihodies in the Study of Blood Coagulation.

Cecil Hougie, MD
Arch Intern Med. 1968;121(4):386. doi:10.1001/archinte.1968.03640040080041.
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As the title specifically states, this book describes the use of antibodies in the study of blood coagulation. The first part describes methods used by the author to purify the various clotting factors and to prepare antibodies against them. The second part describes the use of specific antisera in a study of problems of blood coagulation kinetics. With his antisera the author has been able to obtain clotting factors of much greater functional specificity than those prepared solely by conventional biochemical methods, and he has used these to study the kinetic of both intrinsic and extrinsic clotting. His conclusions however do not differ in any important respect from those more recently obtained by others using highly purified factors prepared by conventional methods. One of the major problems in blood coagulation work is the exclusion of unwanted contaminents from complex reactions; and in a study involving the interactions of complex proteins,


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