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Diagnosis and Treatment of Haemophilia.

Ralph O. Wallerstein, MD
Arch Intern Med. 1968;121(4):377-378. doi:10.1001/archinte.1968.03640040071022.
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This attractively priced booklet gives an excellent, practical account of therapy in hemophilia A (anti-hemophilic globulin, factor VIII deficiency). As a guide to therapy for this condition, it is strongly recommended especially to pediatric services.

The diagnostic section and the discussion of other bleeding disorders are less valuable. It also suffers from some provincialism; it is derived from experience with children and adolescents at the Children's Hospital in Boston (as the author himself states on page 14, line 8) without taking sufficiently into account experiences and statistics by other workers in the field. For example, in our experience dealing with a large adult, nonhospitalized group, Von Willebrand's disease is about as frequent as hemophilia, and "de novo" hemophiliacs make up one third of the mild group. Similarly, in countries with good medical records (eg, Switzerland and Finland), a positive history would probably be available in a relatively larger percentage of


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