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Plasma Cell Leukemia With IgD Paraprotein

Isaac Ben-Bassat, MD; Uri I. Frand, MD; Chaviva Isersky, PhD; Bracha Ramot, MD
Arch Intern Med. 1968;121(4):361-364. doi:10.1001/archinte.1968.03640040055012.
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Immunoglobulin D (IgD) has been recently established as a new fourth member of the immunoglobulin family. It was discovered by Rowe and Fahey1 in 1965 in a patient with multiple myeloma and later it was found to be present in the serum of normal human subjects. Its biological functions and roles in the immune mechanisms are still unknown. D-myelomas are quite rare. Only a few reports have appeared in the literature.2-7

In the present communication a patient with plasma cell leukemia with IgD paraprotein will be described. This is, to our knowledge, the first reported case.

Materials and Methods  Routine hematological examinations were performed according to Dacie and Lewis.8 Electrophoresis of serum and urine were done on paper, cellulose acetate, and starch gel according to techniques described by Kohn9 and Smithies.10 Immunoelectrophoresis and immunodiffusion of serum and urine were performed according to Scheidegger,11 and


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