In his introduction to this first volume in what presumably will be a series of annual "reviews," the coordinating editor states that the purpose of the publication will be to "attempt to provide a source of responsible discussion and reliable bibliography in areas of established endeavor which are of current interest." If this is the aim, this first volume is a striking success. But an "annual review of rheumatology" it is not! A clinician searching for a true annual review will find more satisfaction in the Rheumatism and Arthritis Reviews published in the Annals of Internal Medicine.
In this volume, selected subjects of interest to the laboratory investigator, or the inquiring clinician, are thoroughly reviewed. Following a review of the basic concepts of lysosomes and their possible action, a discussion of substances that labilize (endotoxin, virus infection) or stabilize (cortisone, chloroquine) lysosomes serves to emphasize their possible importance in rheumatic