There is an apochryphal tale about the publishing business that a writer would have assured success of his book if he considered the fact that the titles of best sellers over the years contained a reference to either motherhood, a dog, or Abraham Lincoln. The suggested title to guarantee success, therefore, might be "The Dog of Abraham Lincoln's Mother." A modern counterpart in the field of medical science might suggest the author should consider as essential the incorporation of molecular biology, inheritance, and metabolic disease into his title. I do not know the fate (real or apocryphal) of "The Dog of Abraham Lincoln's Mother," but I am certain of the well-deserved acceptance of the Stanbury, Wyngaarden, Fredrickson text, The Metabolic Basis of Inherited Disease, as the "standard reference" in the field.
The reader, by assidous perusal, can pick up small flaws and can point out some clinical descriptions that are