0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Group C Monosomy in Myelofibrosis With Myeloid Metaplasia

John F. Jackson, MD; Leonard C. Higgins Jr., MD
Arch Intern Med. 1967;119(4):403-406. doi:10.1001/archinte.1967.00290220153014.
Text Size: A A A
Published online

ALTHOUGH chromosome analysis in myeloproliferative disorders has usually confirmed a normal chromosome pattern, several reports of patients with various chromosome abnormalities have appeared.1-7 Most of these patients had received irradiation or chemotherapy prior to chromosome analysis. The purpose of this report is to record a case of myelofibrosis with myeloid metaplasia in which cytogenetic study of peripheral blood prior to treatment revealed a missing C group chromosome.

Report of a Case  A 54-year-old white salesman was admitted to the Veterans Administration Hospital with a two year history of easy fatigability. Six weeks prior to admission he had consulted his physician for treatment of an ischiorectal abscess when, for the first time, anemia and hepatosplenomegaly were discovered. Multiple bone marrow aspirations were "dry," but an open marrow biopsy of the right iliac crest revealed fibrosis. For this reason the patient was referred for continued study. Prior to referral, therapy consisted

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();