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Group C Monosomy in Myelofibrosis With Myeloid Metaplasia

John F. Jackson, MD; Leonard C. Higgins Jr., MD
Arch Intern Med. 1967;119(4):403-406. doi:10.1001/archinte.1967.00290220153014.
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ALTHOUGH chromosome analysis in myeloproliferative disorders has usually confirmed a normal chromosome pattern, several reports of patients with various chromosome abnormalities have appeared.1-7 Most of these patients had received irradiation or chemotherapy prior to chromosome analysis. The purpose of this report is to record a case of myelofibrosis with myeloid metaplasia in which cytogenetic study of peripheral blood prior to treatment revealed a missing C group chromosome.

Report of a Case  A 54-year-old white salesman was admitted to the Veterans Administration Hospital with a two year history of easy fatigability. Six weeks prior to admission he had consulted his physician for treatment of an ischiorectal abscess when, for the first time, anemia and hepatosplenomegaly were discovered. Multiple bone marrow aspirations were "dry," but an open marrow biopsy of the right iliac crest revealed fibrosis. For this reason the patient was referred for continued study. Prior to referral, therapy consisted


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