April 1967, Vol 119, No. 4 >

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ARTICLE | April 1967

The Isoenzymes of Lactic Dehydrogenase: II. Pulmonary Embolism, Liver Disease, the Postoperative State, and Other Medical Conditions

Nelson P. Trujillo, MD; Donald Nutter, MD; John M. Evans, MD

Arch Intern Med. 1967;119(4):333-344. doi:10.1001/archinte.1967.00290220083003.

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The DETERMINATION of serum lactic dehydrogenase (LDH) activity is used in the diagnosis of a wide variety of conditions such as myocardial infarction,¹ pulmonary embolism,² hepatobiliary diseases,³ musculoskeletal disorders,⁴ certain neoplasms,⁵ and a variety of hematological diseases.⁶ Hence, to a considerable degree, this enzyme lacks specificity as a diagnostic aid. The separation of LDH into its component isoenzymes represents an attempt to improve its specificity.

Lactic dehydrogenase in man consists of five heterogenous isoenzymes. Lactic dehydrogenase 1, the electrophoretically slowest isoenzyme, is present in largest concentration in liver and skeletal muscle, while LDH 5, the electrophoretically fastest isoenzyme, is found in largest concentration in heart muscle and erythrocytes. Lactic dehydrogenase 2, 3, and 4 are distributed widely and in varying amounts in reticuloendothelial, lung, heart, and other tissues.⁷ It has been assumed that serum LDH isoenzyme activity in disease states reflects, at least in part, the isoenzyme activity of tissue

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Trujillo NP, Nutter D, Evans JM. The Isoenzymes of Lactic Dehydrogenase: II. Pulmonary Embolism, Liver Disease, the Postoperative State, and Other Medical Conditions. Arch Intern Med. 1967;119(4):333-344. doi:10.1001/archinte.1967.00290220083003.

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The Isoenzymes of Lactic Dehydrogenase: II. Pulmonary Embolism, Liver Disease, the Postoperative State, and Other Medical Conditions

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