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Article |

Aplastic Anemia and Splenectomy

Joe L. Koch, MD
Arch Intern Med. 1967;119(3):305-306. doi:10.1001/archinte.1967.00290210137015.
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THE GRAVE prognosis associated with aplastic anemia is well established and has been repeatedly documented.1-3 Various regimens have been explored in the management of this disease. These include either alone or in combinations, adrenocorticosteroids, androgens, and splenectomy.2,4 6 Varying degrees of success have been reported and a number of remissions have been reported.4-6 Despite these experiences, spontaneous remission has been the elusive goal of all treatment programs. In 1962 and in 1965, Lewis described a hemolytic component which may be present in aplastic anemia and reported the possible beneficial effects of splenectomy; however, in none of his cases were radioisotope studies used for the detection of splenic sequestration prior to splenectomy.3,7 In 1965, Ingall et al reported that phenylalanine mitigated certain toxic effects induced by chloramphenicol.8 It is the purpose of this report to describe a patient with aplastic anemia, who exhibited a partial remission following splenectomy.

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