The 18 dissertations and the discussion of them at a symposium on rheumatology held in Bad Nauheim, Germany, April 24-26, 1964, provide both orientation and stimulation for physicians interested in the rheumatic diseases. They summarize considerable existing knowledge and add add some new personal observations of the investigators.
Research with histochemical models, of keratosufate transformation, in molecular pathology, of mesenchymal and cartilaginous metabolism, and in the biochemical alterations of synovial fluid demonstrate important precursors of the rheumatic state. In the fibrositis syndrome, intramuscular pressure was elevated as shown by manometric readings and the circulation was impaired as shown by delayed disappearance of radioactive iodine from a depot. Primary metabolic abnormalities produce secondary skeletal manifestations; special attention is given to phenylalanine and tyrosine, ochronosis, thyroid activity, and diabetes. This is the 36th volume of a series of detailed presentations in the field of rheumatic diseases published since the founding of the