THE INCREASING use of chlorpromazine (CPZ) has led to an increasing awareness of its potential ability to cause agranulocytosis 1-4 and the studies of Pisciotta and his co-workers have led to a better understanding of the mechanisms by which this toxic effect is produced.5-8 By contrast, anemia, either hemolytic 9,10 or aplastic, is a much rarer manifestation of the potential bone marrow toxicity of this agent. Aplastic anemia with pancytopenia has been reported in one case by Shelton et al 11 and a total of 24 cases of this type of anemia following the administration of CPZ has been reported to the AMA Council on Drug Reactions.12
The mechanisms by which this drug might produce anemia have not been studied. It would seem unlikely that the abnormalities of deoxyribonucleic acid synthesis in leukocytes resulting from CPZ administration described by Pisciotta et al would only affect the single
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 2
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.