RECENT investigation of the biochemical nature of the reparative processes following myocardial infarction indicates that there is a rapid response to the injury and early commencement of reparative processes in heart muscle.1,2 The reparative processes, as manifested by incorporation of radioactive glycine into protein and nucleic acids, have been shown to start in the nucleolus a few hours after infarction. Subsequently, there is an increase in synthetic activity of nuclear ribosomes, followed by reconstruction of mitochondria and microsomes.
The purpose of this study was to attempt to stimulate these reparative processes following experimental myocardial infarction by treatment of the animal with anabolic hormones, such as growth hormone, insulin, and anabolic steroids. The effects of low molecular weight substances known to stimulate wound healing, such as ascorbic acid, were also studied and will be reported.
Materials and Methods
Myocardial infarction was produced in mongrel dogs (10-15 kg) under pentobarbital anesthesia