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Metabolic Balance of Obese Subjects During Fasting

ROBERT E. BOLINGER, MD; BARBARA P. LUKERT, MD; ROBERT W. BROWN, MD; LILIA GUEVARA, MD; RUTH STEINBERG, MS
Arch Intern Med. 1966;118(1):3-8. doi:10.1001/archinte.1966.00290130005002.
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Regardless of the approach to the management of obesity, final reliance must be placed upon the induction of a negative caloric balance in order for there to be any significant loss of fat.1 In most cases this can be accomplished by restriction of the dietary intake which many patients are unable or unwilling to maintain for any significant length of time. Although a rational interpretation of nutritional data teaches us that general health can best be sustained during weight reduction by use of a balanced diet deficient only in calories and maintained over a protracted period, regimens designed for rapid weight loss continue to be attractive to many. The concept of the total starvation diet as an adjunct to the treatment of obesity has been introduced by Bloom2 and used extensively by Duncan and coworkers.3,4 The presumed success of this approach stems at least in part from

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