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Acquired Hemolytic Anemia With Positive Antiglobulin (Coombs' Test) in Mother and Daughter

Arch Intern Med. 1966;117(5):692-695. doi:10.1001/archinte.1966.03870110084017.
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I T IS generally accepted that autoimmune diseases are interrelated, and recent studies have shown that a genetic predisposition may be the connecting factor.1,2 These conditions have been reported among members of the same family and sometimes different forms occur in the same person or in members of the same family. The familial incidence of collagen disease, such as lupus erythematosus (LE) and arthritis, is well known.3-6 On the other hand, familial examples of acquired hemolytic anemia are rare.7-10 The present paper is concerned with the observation of acquired hemolytic anemia in a mother and her daughter.

Report of Cases 

Case 1.  —The proband 11-year-old girl had a history suggestive of hemolytic anemia. Approximately three years prior to admission, she began to have anemia, plus jaundice, which were controlled by blood transfusions and corticosteroids. She was first admitted to our hospital in August 1960 with complaints of


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