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Familial Chronic Discoid Lupus Erythematosus and Hypergammaglobulinemia

Arch Intern Med. 1966;117(5):627-631. doi:10.1001/archinte.1966.03870110019004.
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THE FAMILIAL occurrence of chronic discoid lupus erythematosus (CDLE) and systemic lupus erythematosus (SLE) has been reported previously. In 1957 Leonhardt tabulated 40 cases of CDLE and four cases of SLE in which such a familial relationship had been mentioned.1 Included in his study were three sisters with SLE and several asymptomatic siblings with hypergammaglobulinemia.1 A search of the literature has revealed no reports of SLE or CDLE occurring in more than two consecutive generations and no studies regarding the existence of familial hypergammaglobulinemia in asymptomatic relatives of patients with CDLE.

This paper is a report of a family in which hypergammaglobulinemia has been demonstrated in four consecutive generations and CDLE in three consecutive generations.

Material and Methods  Three Negro women, first degree relatives with CDLE, were studied in the Outpatient Department of the Jefferson Medical College. The diagnosis was established by history, clinical appearance of the


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