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Perfusionstheorie der Arteriosklerose.

William H. Wehrmacher, MD
Arch Intern Med. 1966;117(3):457-458. doi:10.1001/archinte.1966.03870090141028.
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Edited by Daniel B. Stone, MB

Although a perfusion theory of the genesis of arteriosclerosis is by no means new and sponsorship by eminent men is by no means lacking, the fresh approach of Professor Doerr of Heidelberg can be expected to generate real interest and should promote new studies to control it. In the middle of the 19th century, Rokitansky proclaimed that atherosclerosis was due to the encrustation of fat on the intimal surface of the artery and Virchow disagreed and considered it to be the result of imbibition of lipid. In 1946, Duguid proposed that it is the result of intimal thrombosis. All these apparently contradictory theories find support and clarification in Doerr's comprehensive exposition.

Doerr gathers evidence showing that banal arteriosclerosis of the aorta begins as mucopolysaccharides sequestrate from the fluid portions of the blood which constantly perfuses through the wall of the aorta from its major


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