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Coexistent Systemic Lupus Erythematosus and Porphyria

Arch Intern Med. 1966;117(3):425-428. doi:10.1001/archinte.1966.03870090109021.
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WHILE the association of two or more diseases in a patient is not uncommon, such an association between two relatively uncommon disorders in two patients within a short period of time is impressive. This type of observation may be helpful in providing basic understanding and in directing investigation of mechanisms responsible for either or both disorders. It is this consideration which has led to the report of two patients recently studied on this service. Both had systemic lupus erythematosus (SLE). One exhibited clinical and biochemical characteristics of acute intermittent porphyria, and the other of porphyria cutanea tarda.

Report of Cases 

Case 1.  —A 31-year-old Caucasion female house-wife noted the onset of urticaria, myalgia, swelling and pain in the wrists, ankles, knees, and temporomandibular joints 48 hours aften an injection of killed poliomyelitis virus on Nov 28, 1961. Remissions and exacerbations of these symptoms occurred despite treatment with antihistamines, corticotropin,


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