THE FAMILIAL occurrence of hyperparathyroidism is uncommon and only 13 families have been previously reported.1 However, there are many remarkable clinical, pathologic, and genetic similarities between this disorder and the syndrome of multiple adenomatosis.1,2 In fact, it has been suggested that familial hyperparathyroidism may be only a partial expression of the latter.1 Wermer 3 has pointed out that clinical manifestations of multiple adenomatosis may be initially confined to a single endocrine gland and the parathyroid gland is the primary site of involvement in this syndrome.2
This communication contributes an additional family with three involved members and contrasts the pathologic material with that of preceding reports. In addition, attention is focused on the need for the screening of members of a family to find and study asymptomatic individuals.
Report of Cases
—This 53-year-old white woman was found to have an elevated serum calcium after a ureterolithotomy. Polyuria, dysuria, and
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