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March 1966, Vol 117, No. 3 >
ARTICLE | March 1966

The Clinical Significance of Fever in Hodgkin's Disease

M. LOBELL, MD; D. R. BOGGS, MD; M. M. WINTROBE, MD, PhD
Arch Intern Med. 1966;117(3):335-342. doi:10.1001/archinte.1966.03870090019004.
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Fever is a frequent manifestation of Hodgkin's disease occurring in 30% to 60% of patients during the course of their disease.1,2 The presence of fever presents a diagnostic and therapeutic challenge. Fever is recognized as an intrinsic part of the clinical picture of Hodgkin's disease3 but increased susceptibility to infections also is present.1,4 Therefore, the physician must determine whether or not fever is due to infection and act accordingly. Indiscriminate administration of antibiotics to such patients in the absence of infection is of no benefit and may actually be harmful.5 Therefore distinction between fever due to infection (FI) and fever apparently due to the disease itself (fever of Hodgkin's disease, FHD) is of practical significance as well as of academic interest.

In this study we attempted to find specific parameters which might help in differentiating FI from FHD. One hundred and twenty-four febrile episodes which developed between diagnosis and death

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