This reviewer finds it difficult to evaluate volume 4 of the series, Standard Methods of Clinical Chemistry, without making some comments on the entire series. Evaluation of clinical chemical procedures is a time-consuming and difficult task. Often laboratory procedures are selected on a somewhat hit-or-miss basis with the avowed intent to evaluate the procedure more fully at a later time and compare it to rival procedures. Too often the pressures of work force long or indefinite postponement of the evaluation.
When one attempts to establish a procedure in a laboratory by using the guide lines given in most journal reports, certain difficulties arise. Frequently a method is presented with minimal directions and minimal evaluation statistics. The method may well be everything the author states if the circumstances of his laboratory are duplicated. Unfortunately many times one must derive the exact directions for reproducible and accurate results by trial and error