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Sodium Ampicillin Given Parenterally

MARVIN TURCK, MD; RONALD H. SMITH, MD; JAMES F. WALLACE, MD; ROBERT G. PETERSDORF, MD
Arch Intern Med. 1966;117(2):242-249. doi:10.1001/archinte.1966.03870080086013.
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AMPICILLIN, is a semisynthetic penicillin which is effective against penicillinsusceptible gram-positive organisms as well as many prevalent gram-negative pathogens.1-7 The oral preparation in clinical use which consists of the free acid of ampicillin has been under extensive trial since 1961 and was made available commercially in the United States in 1964. Several studies have indicated that it is fairly stable in the presence of gastric acid, and is absorbed readily from the gastrointestinal tract; is not bound to protein in appreciable quantity; is distributed well into most tissues; and generally is well tolerated and safe.8-10 Less is known regarding the sodium salt of ampicillin which recently has been made available for parenteral administration.11-14 This report describes the use of the sodium salt of ampicillin in the treatment of 124 hospitalized patients with a variety of systemic infections.

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Selection of Patients.  —Patients admitted to the General Medical and

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