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Severe Peripheral Arterial Constriction, Acute Ischemia of Lower Extremity With Use of Methysergide and Ergotamine

Arch Intern Med. 1966;117(2):237-241. doi:10.1001/archinte.1966.03870080081012.
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THE DEVELOPMENT of methysergide (Sansert) for the management of individuals with frequently recurring vascular headache has been a welcome adjunct to their care. This agent has the property of preventing or decreasing both the vasoconstrictor phase as well as the vasodilator phase responsible for the pain of migraine and allied head pains.1 It has been used, therefore, as prophylactic therapy for individuals with frequently recurring headaches. The drug is usually well tolerated, side effects ordinarily being transient and mild, including nausea, giddiness or dizziness, epigastric distress, insomnia, difficulty concentrating, and limb pains.2-9 Infrequent reports have occurred which raise the question of vasospastic phenomena, such as the development of intermittent claudication and cramping extremity pains. Acute peripheral ischemic reactions that have required five or more days to subside have occurred in a few. In some of the more severe reactions, there has been concomitant use of other vasoconstricting


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