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Structural and Functional Abnormalities of Liver in Infectious Mononucleosis

Arch Intern Med. 1966;117(1):47-53. doi:10.1001/archinte.1966.03870070061008.
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HEPATIC functional impairment in infectious mononucleosis is nearly universal1,2 and histologic changes in the liver are regularly encountered.3-6 To this time, no study correlating the extent of altered structure and functional abnormalities has appeared. This study presents such a correlation and describes the findings which suggest that the degree of abnormality in certain liver-function tests in infectious mononucleosis is well correlated with the extent of accumulation of mononuclear round cells in the lobular sinusoids.

Materials and Methods  Twenty military patients were admitted to the hospital with the diagnosis of infectious mononucleosis between September 1962 and April 1963. Each had the characteristic clinical picture, atypical lymphocytes in the peripheral blood and diagnostic heterophil titers and adsorption studies.7 Liver-function studies were performed in each case and were repeated at weekly intervals. These included total and one-minute bilirubin, serum alkaline phosphatase (SAP),8 serum glutamic pyruvic transaminase (SGPT),9sulfobromophthalein retention (BSP),10 cephalin cholesterol flocculation,


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