We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Acid-Base Problems in Hypothermia

Arch Intern Med. 1965;116(5):739-742. doi:10.1001/archinte.1965.03870050093013.
Text Size: A A A
Published online


THE USE OF hypothermia to reduce metabolism has introduced new problems in the acid-base field. Since induced hypothermia necessitates artificial ventilation of the patients, knowledge of the correct Pco2 and pH at which to maintain these patients is essential. This calls for determinations of blood pH and Pco2 in hypothermic patients. As a result methodological and theoretical problems have arisen. How should these measurements be carried out? At the usual measuring temperature (37 C or 38 C), or at the temperature of the patient, or at both temperatures? In any case it is necessary to know how the change of temperature itself affects the pH and Pco2 of the blood. In this paper we will discuss physicochemical and methodological problems of pH and Pco2 measurements at different temperatures as well as some physiological problems.

Physicochemical and Methodological Problems  The acid-base changes of plasma and whole blood with temperature are caused


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

5 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.