0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Metabolic Acidosis—Diabetic

FRANK Q. NUTTALL, MD
Arch Intern Med. 1965;116(5):709-716. doi:10.1001/archinte.1965.03870050063010.
Text Size: A A A
Published online

METABOLIC ACIDOSIS is a clinical state characterized by an excess of hydrogen ions, the source of which are acids other than carbonic. In diabetic acidosis, the source of the excessive hydrogen ion is ketoacids formed during the process of intermediary metabolism in the absence of insulin. The degree of acidemia, ie, lowering of arterial blood pH, will depend on the severity of the metabolic disturbance on the one hand and the efficiency of the compensating mechanisms on the other. Reductions in arterial blood acid-base parameters, pH, [HCO3—], and Pco2, define the pattern of the metabolic acidosis. Reduction in Pco2 is a reflection of the compensatory hyperventilation (Kussmaul respiration) occurring presumably in response to the lowered pH. If untreated, diabetic acidosis is fatal.

History1  Stadelmann 2 in 1883 was the first to recognize that the symptom complex of diabetic coma was similar to the acid intoxication produced in rabbits by Walter.3

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 2

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();