The papers that follow are based upon a symposium held at the Minneapolis Veterans Hospital on Oct 4 and 5, 1962. The enthusiastic reception of the talks presented at the time and the continued inquiries for copies of the mimeographed papers which were distributed have led to the decision to rework the original papers, bring them up to date, and make them available to a wider audience.—Ed.
CLINICAL application of the established facts in the field of acid-base balance has been difficult for many years because of cumbersome methodology which restricted pH and Pco2 determinations almost exclusively to research laboratories. During the past decade, however, techniques suitable for routine clinical laboratory use have been available, making possible the direct bedside application of existing knowledge and potential additional advances through clinical investigation. Unfortunately, progress in the many obscure facets of acid-base balance has been hampered by a variety of misconceptions still