Clinical pharmacology is one of the newest and most rapidly growing academic disciplines in medical schools in this country in the last ten years. The modern clinical pharmacologist has many interests. His work is concerned with drug metabolism, mechanism of action of drugs, efficacy and safety of agents given to man, and fundamental studies in which he may use drugs to shed light on the causes of various disease states. He may plan and carry out controlled clinical trials of new drugs in man. Several books have been written on this latter subject in the last few years. Herrick and Cattell have gathered together several papers, most of which have already been published "in somewhat different form" in The Journal of New Drugs, and added several articles written by members of the Food and Drug Administration, as well as copies of the pertinent new drug regulations and forms.