0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Intravenous Metyrapone Test in Chromophobe Adenoma

BYONG S. MIN, MD; V. WILLIAM COLE, MD
Arch Intern Med. 1965;116(4):581-585. doi:10.1001/archinte.1965.03870040095019.
Text Size: A A A
Published online

Introduction  BECAUSE of the recent innovation of the metyrapone test as a measure of endogenous ACTH reserve,1,2 methodological variations on this technique have not been clarified. The dosage, route, and time of day the drug is administered are as important to the final result of the test as is the selection of the appropriate steroid analytical procedures.3 The paucity of reports concerning use of the intravenous route of administration and the current controversy over the results even in normal individuals 4 prompt us to report our experience.This study documents the findings in control subjects and in patients with chromophobe adenoma of the pituitary gland. Increments in the total urinary Porter-Silber chromogens which occurred after the administration of intravenous metyrapone were employed as an indirect measure of pituitary adrenocorticotrophic hormone (ACTH) reserve.

Materials and Methods  Thirteen control subjects and eighteen patients with chromophobe adenoma seen at The University

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();