October 1965, Vol 116, No. 4 >

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ARTICLE | October 1965

Cytomegalovirus Infection After Renal Transplantation

DAVID RIFKIND, PhD, MD

Arch Intern Med. 1965;116(4):554-558. doi:10.1001/archinte.1965.03870040068014.

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CHARACTERISTIC basophilic intranuclear inclusion body-containing cells morphologically compatible with viral infection were observed in autopsy lung specimens from 15 of 32 patients treated at this center by means of organ transplantation.¹ These inclusions have been demonstrated in the brains of two patients and in an additional ten cases other histologic evidence of viral CNS infection was present.² In three patients the inclusion body-containing cells were also disseminated to the lymph nodes, liver, pancreas, parathyroid, and salivary glands.¹ In addition, a segment of donor ureter resected 228 days posttransplant because of stricture also contained these inclusions.³

It is the purpose of this communication to report the isolation and identification of a viral agent from the lungs of three patients who died following renal homotransplantation.

Methods

Tissue Culture. —Specimens of lung obtained at autopsy were ground to approximately a 10% suspension in tissue culture medium. This consisted of Eagle's minimal essential medium

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RIFKIND D. Cytomegalovirus Infection After Renal Transplantation. Arch Intern Med. 1965;116(4):554-558. doi:10.1001/archinte.1965.03870040068014.

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