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Tay-Sachs Disease.

Walter C. Alvarez, MD
Arch Intern Med. 1965;116(3):480-481. doi:10.1001/archinte.1965.03870030160058.
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This book is well worth noting, because Tay-Sachs disease is common enough to be very distressing. As we all know, it is a hereditary disease which attacks mainly Jewish people. It is an "inborn error of metabolism." Soon after birth the poor child begins to fail in mental and physical health, and before long he begins to lose his sight. In nine out of ten patients there is a cherryred nodule in the macula. Retinal hemorrhages are a frequent occurrence in the eyes of the newborn, and a hemorrhage may be confused with a cherry-red spot. Often the child shows muscular hypotonicity; there may be seizures, and the electroencephalogram can be stormy. By the third or fourth month of age, the child shows weakness and inability to hold up his head. One out of four of the children show excessive irritability to bright light during the first six months


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