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Cerebral Salt-Wasting Associated With the Guillain-Barré Syndrome

Arch Intern Med. 1965;116(1):113-119. doi:10.1001/archinte.1965.03870010115014.
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INAPPROPRIATE secretion of antidiuretic hormone has been implicated as the cause of the hyponatremia and renal salt-wasting associated with certain cases of intracranial and intrathoracic disease. Cases of traumatic, infectious, and neoplastic intracranial disease, and of neoplastic thoracic disease have been associated with the salt-wasting syndrome.1-6 The following is a report of the simultaneous occurrence in a patient of an illness clinically indistinguishable from the Guillain-Barré syndrome and of an electrolyte disturbance marked by transient loss of renal sodium-conserving ability, plasma hypo-osmolality, and plasma hyponatremia. Immunologic features of this patient's illness suggested to us that the etiology of the polyradiculoneuropathy was hypersensitivity to viral antigens.

Report of a Case  A 32-year-old Taiwanese man, a virology technician at the US Naval Medical Research Unit No. 2 (NAMRU-2), was admitted to Taiwan University Hospital on Sept 16, 1961, with the chief complaint of walking disturbance and pain in the left


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