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Radioactive Iodine Uptake in Hashimoto's Thyroiditis

Arch Intern Med. 1965;116(1):111-112. doi:10.1001/archinte.1965.03870010113013.
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HASHIMOTO'S thyroiditis has been the subject of much attention during the past few years, especially from the standpoint of its immunologic implications. The incidence of this condition appears to be increasing.1 Diagnosis on a clinical basis is not always easy and laboratory aid frequently must be used. In two major textbooks 2,3 and a number of recent articles,4-6 the 24-hour uptake of radioactive iodine (131I) in Hashimoto's thyroiditis has been described as either normal or increased, a characteristic which would be important in differentiating this condition from other causes of nontoxic goiter.7 Our experience differs from these findings and suggests that the 24-hour radioactive iodine (131I)uptake in Hashimoto's thyroiditis is extremely variable and nonspecific and has no diagnostic significance.

Materials and Methods  All patients with Hashimoto's thyroiditis diagnosed at Letterman General Hospital from January 1960 to November 1964 having undergone surgical biopsy or excision were reviewed. The pathologic diagnosis in


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