TUBERCULOSIS has been associated with a variety of hematological abnormalities. These include hypoplasia of the bone marrow,1,2 myelofibrosis,3-5 and polycythemia.6 Tuberculosis is sometimes associated with a leukemoid reaction which must be differentiated from leukemia. In 1911 Coley and Ewing,7 from postmortem studies, first drew attention to the leukemoid response which may be evoked by tuberculosis. The association was first made antemortem by Mills and Townsend 8 in 1937. We have found only 38 reports of patients who had leukemoid reactions to tuberculosis which fulfilled the following criteria: (1) tubercle bacilli had to be demonstrated and (2) an excessive leukocytosis or an abnormal shift towards immaturity in the peripheral blood or in the bone marrow. A diagnosis of leukemia was considered to be excluded if a lasting hematologic recovery occurred or if visceral infiltration with leukocytes could not be demonstrated at autopsy.
It is the purpose of this paper to discuss
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 43
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.