0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Diuretic Action of Furosemide

DUNCAN E. HUTCHEON, MD, PhD; DILIP MEHTA, MD, PhD; ANNA ROMANO
Arch Intern Med. 1965;115(5):542-546. doi:10.1001/archinte.1960.03860170024006.
Text Size: A A A
Published online

RECENTLY Kleinfelder1 reported that furosemide, a new monosulfamylanthranilic acid derivative, produced a prompt diuretic response in patients with edema. Preliminary observations indicated that the diuretic action of furosemide was appreciably different from that of chlorothiazide diuretics and carbonic anhydrase inhibitors in terms of chloride excretion, duration of action, and therapeutic efficacy.2,3

In the present study, changes in renal electrolyte and water excretion caused by furosemide were observed in normal subjects and in patients with chronic congestive heart failure. Experiments were designed to observe the diurnal variations in renal electrolyte and water excretion during furosemide therapy and to compare the diuretic response to furosemide with that produced by chlorothiazide diuretics and carbonic anhydrase inhibitors.

Methods  The diuretic action of furosemide was evaluated in three separate studies: (1) in normal subjects, changes in renal electrolyte excretion patterns produced by furosemide were compared with those caused by other sulfamyl drugs; (2) diuretic effects

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 45

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();