METASTATIC malignant disease to bone is known to cause hypercalcemia.1-5 In nonmetastatic cases, the occasional findings of associated serum and urinary phosphorus abnormalities and the disappearance of the hypercalcemia with the removal of the tumor suggest a relationship to a hyperparathyroid state.3-27
The following case report of nonmetastatic bronchogenic carcinoma demonstrates the typical features of hyperparathyroidism and their reversal by surgical removal of the tumor.
Report of Case
A 66-year-old Caucasian man was hospitalized for evaluation of an intrapulmonary mass on June 18, 1963. He had been in excellent health all his life until three months prior to admission when he noted the onset of cough, anorexia, dysphagia and a 20 lb (9.1 kg) weight loss. There were no other pulmonary, cardiac, renal, or metabolic symptoms. The patient's past history revealed that he had smoked 1½ packs of cigarettes a day for 40 years.Physical examination revealed a