Colchicine Toxicity

Arch Intern Med. 1965;115(1):29-33. doi:10.1001/archinte.1965.03860130031005.
Text Size: A A A
Published online

CRETAIN toxic effects of colchicine, such as malaise, anorexia, nausea, vomiting, abdominal pain and diarrhea, are well recognized. Less well known toxic effects of colchicine include fever, alopecia, liver damage, and extensive damage to the nervous and hematopoietic system. In this report, a patient is described who manifested almost all the toxic effects of colchicine, and the literature is reviewed.

Report of Case  A 36-year-old white married man was admitted to the National Institutes of Health Clinical Center on March 26, 1962, for evaluation of gouty arthritis and renal failure. Attacks of arthritis, first noted at the age of 19, had been intermittent and had been relieved by colchicine, aspirin, and corticotropin (ACTH). They had increasing severity so that the patient had been incapacitated for the six months prior to his admission. It was known that serum creatinine and blood urea nitrogen had been elevated at least two years before


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.