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Clinical Genodermatology.

John M. Opitz, MD
Arch Intern Med. 1964;114(5):723-725. doi:10.1001/archinte.1964.03860110193045.
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Dermatology has always impressed me as an admirable medical subspecialty with its neatly circumscribed field of action. Dermatology holds particular fascination for the medical geneticist. In no other specialty are the lesions displayed so clearly for all to see if they would but look with seeing eyes, nor have they been studied so thoroughly in any other specialty; and this has led to the rapid accumulation of a surprisingly vast store of knowledge which the average dermatology house-officer can barely master during his residency. This applies most of all to the hereditary and constitutional skin disorders, whose number is legion and whose inheritance is frequently complex and obscure, whose penetrance is rarely complete, and whose expressivity is notoriously variable; they frequently mimic environmentally produced lesions (genocopies) and are just as frequently imitated by the environment as phenocopies. This is also the specialty par excellence in which the recognition of the


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