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Congenital Abnormalities in Infancy.

John M. Opitz, MD
Arch Intern Med. 1964;114(5):713-715. doi:10.1001/archinte.1964.03860110183035.
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As a pediatric type of internist, the reviewer enjoyed reading this book and reviewed it with the greatest pleasure. This is a timely and excellent work on the urgent and important subject of developmental pathology in human medicine. The study of this field is just in its infancy and the recent symposia and monographs 1-7 dealing with congenital anomalies are barely beginning to state the problem, to define its magnitude, to attempt a nosologic classification, and to attain some primordial insight into the causal and formal genesis of some anomalies. Interest in this subject has been intensified recently by several events: the thalidomide disaster, which raised the fearful question about the extent of environmentally produced mutations and developmental anomalies in man; the advent of new cytogenetic methods which are being applied to the problem of congenital anomalies, and the application of sophisticated biochemical techniques to the search for inborn errors


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