Personal friendship with the author perhaps ought to disqualify me from undertaking this review; I believe, however, that X-linked inheritance and the evolution of McKusick's career should hold equally great interest for the American internist.
McKusick received his medical education at Johns Hopkins, where he is now Professor of Internal Medicine and Chief of the Division of Medical Genetics. His interests naturally evolved from cardiology, in which he has achieved renown with an excellent textbook on phonocardiography, to a study of Marfan's syndrome and the heritable disorders of connective tissue, on which he has written his best known monograph, namely: Heritable Disorders of Connective Tissue. From there the next logical step was nothing less than a study of heredity in medicine. In this area McKusick rapidly established himself not only as one of the most erudite, gifted, and versatile of teachers but also as one of the world's great synoptic