Submetacentric Chromosome in Chronic Myelocytic Leukemia

Arch Intern Med. 1964;114(3):439-443. doi:10.1001/archinte.1964.03860090173021.
Text Size: A A A
Published online

Introduction  A chromosomal aberration has been described in chronic myelocytic leukemia.1-7 This abnormal chromosome appears to belong to the small acrocentric chromosome group with deletion of part of the long arms of one of these chromosomes. It has been named "Philadelphia" or "Ph1." In addition to this chromosome found in chronic myelocytic leukemia, another small, minute chromosome has been reported in a case of this disease.4 Recently, Warkany et al 8 reported chromosome analysis of a case of mongolism associated with acute myeloblastic leukemia. They found a typical trisomy-21 mongolism in this patient; but, in addition, an extra medium-sized submetacentric chromosome was found in the cells cultured from the peripheral blood leukocytes. This chromosome resembled the chromosomes of the group 6-12 and X of the Denver classification.9 Additional chromosomes of similar morphology have been reported in cases of acute myeloblastic leukemia.10,11A patient with chronic


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.