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Intestinal Localization of Waldenstrom's Disease

Arch Intern Med. 1964;114(3):399-407. doi:10.1001/archinte.1964.03860090133014.
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Since Waldenstrom's1 original description of macroglobulinemia in 1944, several reports on isolated cases or series have appeared in the literature.2,8,10-22 Fewer reports have been concerned with autopsied material.9 In only two patients has the intestinal involvement been severe enough to cause a prominent diarrhea among the clinical manifestations.16,22 It is our purpose to report one case of primary macroglobulinemia of Waldenstrom in which small intestine involvement was particularly severe and in which a postmortem examination was performed.

Clinical Summary  The patient was a 64-year-old white man who came to Roswell Park Memorial Institute 14 months before death with the chief complaint of painless and asymptomatic mass in his left upper abdomen for a period of two months. Thirteen months before death, the patient developed inter- mittent, painless diarrhea with three to four, occasionally abundant, loose, yellow-brown or greenish-brown stools without blood or mucus. Meteorism was present.


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