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ARTICLE |

Hemoglobin D in an Oklahoma Family

CLARKE STOUT, MD; CHARLES K. HOLLAND, MD; ROBERT M. BIRD, MD
Arch Intern Med. 1964;114(2):296-300. doi:10.1001/archinte.1964.03860080146016.
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Introduction  In 1952 Itano 1 reported the finding of a new hemoglobin which migrated electrophoretically in the same position as hemoglobin S. This new hemoglobin was found to be much more soluble than hemoglobin S, and the erythrocytes which contained it could not be induced to sickle. It was assigned the letter D. Since then hemoglobin D has been found in Sikhs in India,2 in Algerian Moslems,3 in a Persian girl,4 in a Turkish family,5 and in others.6-8 In a survey of 1,000 Negroes in St. Louis, Chernoff found four instances of hemoglobin D trait.9 In Baltimore, four cases of hemoglobin D trait were found in a survey of 400 Negroes with hemoglobin S trait.10 Several white families have been described in which hemoglobins S and D were present simultaneously.11,12 Homozygosity for Hgb D has been seen infrequently. The reason for this is not clear, since the

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