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Renal Tubular Necrosis Caused by Mushroom Poisoning:  Renal Biopsy Findings by Electron Microscopy and Use of Peritoneal Dialysis in Treatment

RICHARD K. MYLER, MD; JOHN C. LEE, MD; JAMES HOPPER, MD
Arch Intern Med. 1964;114(2):196-204. doi:10.1001/archinte.1964.03860080046003.
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The first deaths from mushroom toxicity in the United States were reported in 1871 by Cheney 1 in Chico, Calif. Cases of fatal mushroom poisoning are seen fairly frequently in Central Europe2,3; the incidence in the United States, however, is low. The United States National Registry of Death recorded only 21 deaths from mycetism from 1957 to 1962. Although fatalities are rare, the admission of a patient with mushroom poisoning to the hospital calls for immediate and knowledgeable care, and the use of special techniques such as peritoneal dialysis or hemodialysis may be required to prevent death.

Two patients with mushroom poisoning were recently referred to the University of California Medical Center, where they were treated by intermittent peritoneal dialysis. The first case, a typical example of severe mushroom toxicity, ended in the patient's death. The second case is unique, in that renal tissue obtained by biopsy was examined

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