Norethynodrel in The Treatment of Factor X Deficiency

Arch Intern Med. 1964;114(1):89-94. doi:10.1001/archinte.1964.03860070135017.
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The demonstrated improvement of factor X (Prower-Stuart factor) deficiency during pregnancy,1 and the further demonstration by Alexander and Pechet 2 of increased clotting factors during pregnancy, has prompted the use of norethynodrel, a progestational agent, in the control of this clotting disorder.

The case to be reported has been the subject of a previous paper by Brody and Finch 1 wherein the factor X deficiency was first documented and its improvement during pregnancy demonstrated.

Report of a Case  The patient is a 31-year-old married woman who has suffered intermittently from a bleeding tendency since the age of 5. This first became manifest when a tonsillectomy was followed by severe hemorrhage from the operative site. At the age of 7 the patient was hospitalized because of hematuria, epistaxis, and bleeding from the gums. Bleeding stopped after an unknown number of blood transfusions, and she was discharged with a diagnosis of


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