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Polyostotic Fibrous Dysplasia And Acromegaly

Arch Intern Med. 1964;114(1):40-45. doi:10.1001/archinte.1964.03860070086008.
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In 1937 Albright and co-workers1 described a syndrome consisting of disseminated fibrous dysplasia of bones, cutaneous pigmentation, and precocious menstruation. There has been considerable interest in this syndrome since that time because of its unexplained pathogenesis and relationship between the endocrine abnormality and the bone disease. The association of hyperthyroidism with this syndrome has been well documented.2 Several cases have been reported 3-5 in which the coexistence of acromegaly and polyostotic fibrous dysplasia has been suggested, but not proved.

The purpose of this report is to describe a patient with definite evidence of both Albright's syndrome and acromegaly with a pituitary tumor.

Report of a Case  A 38-year-old white female (UM No. 592113) was first admitted to the University Hospital in June, 1946, at the age of 22. She had noted the onset of pain in the left leg in March, 1946, followed by pain in the right


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