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Prolonged Remission of Myeloma With Cyclophosphamide

Arch Intern Med. 1964;113(5):758-763. doi:10.1001/archinte.1964.00280110138025.
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This is the case report of a man with multiple myeloma, with hypergammaglobulinemia, hypercalcemia, and uremia, who has had three separate remissions while being treated with cyclophosphamide. The bone marrow has been followed on serial punctures and has, in general, reflected the clinical picture. The electrophoretic pattern, complete blood cell count, serum calcium, and blood urea nitrogen have all returned to normal, and the patient currently is doing well on a maintenance dose of cyclophosphamide.

A 44-year-old single white male was admitted to the Riverside County General Hospital in April, 1960, with a history of weight loss, fatigue and weakness, mental confusion, and a crusting dermatitis of several months' duration. A previous hospital admission in 1943 for an acute schizophrenic episode had shown a normal blood cell count and urine picture.

Physical examination on this admission showed large areas of crusted dermatitis spread over the trunk and arms, with moderately


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