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Amino Acid Excretion in Familial Mediterranean Fever

MELVIN RUBENSTEIN, MD; SHELDON M. WOLFF, MD
Arch Intern Med. 1964;113(3):409-411. doi:10.1001/archinte.1964.00280090095015.
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Introduction  Familial Mediterranean fever (FMF) is a disease characterized by recurrent episodes of fever, peritonitis, or pleuritis,1 which is probably inherited as an autosomal recessive disorder.2 Most of the patients reported with FMF have been of Armenian 3 or Sephardic Jewish ancestry.1 Although the etiology of FMF is unknown, it has been suggested it may be an "inborn error of metabolism" 4 or probably a manifestation of a hypersensitive state.5It was recently reported that some FMF patients excreted increased amounts of urinary histidine as measured by two-dimensional paper chromatography.4,6,7 On the basis of these reports, aminoaciduria has been suggested as a differential diagnostic criterion for FMF.8 We have studied the amino acid excretion with ion-exchange chromatography in five FMF patients both while they were afebrile and pain free and also during spontaneous episodes of fever and peritonitis. The results of these studies demonstrate

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